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Mol Cell. 2006 Apr 21;22(2):150-2.

Reversible monoubiquitination of PCNA: A novel slant on regulating translesion DNA synthesis.

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1
Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.

Abstract

Deubiquitination of monoubiquitinated proteins is effected by a large number of deubiquitinating enzymes (DUBs) that function as cysteine proteases in eukaryotic cells. Huang et al. (2006) report the regulation of monoubiquitination of PCNA by autocleavage of a DUB called USP1 in cells exposed to UV radiation.

PMID:
16630883
DOI:
10.1016/j.molcel.2006.04.002
[Indexed for MEDLINE]
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