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Cell. 2006 Apr 21;125(2):229-31.

Pten, tumorigenesis, and stem cell self-renewal.

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1
Department of Pathology, Stanford University School of Medicine, Beckman Center B259, 279 Campus Drive, Stanford, CA 94305, USA. drossi@stanford.edu

Abstract

Self-renewal pathways crucial for maintaining stem cells are deregulated in cancer, raising the spectre that cancer therapies targeting such pathways might also ablate normal stem cells. As Yilmaz et al. (2006) report in a recent Nature paper, this may not be the case for the tumor suppressor protein Pten, which drives the self-renewal of normal hematopoietic stem cells and the formation of leukemia cells through different mechanisms.

PMID:
16630811
DOI:
10.1016/j.cell.2006.04.006
[Indexed for MEDLINE]
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