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Cancer J. 2006 Mar-Apr;12(2):155-9.

Fractionated proton radiation treatment for pediatric craniopharyngioma: preliminary report.

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Department of Radiation Medicine, Loma Linda University Medical Center, Loma Linda, California 92354, USA.


This retrospective preliminary review evaluated the efficacy and toxicity of fractionated proton radiotherapy in the management of pediatric craniopharyngioma.


Sixteen patients, aged 7-34 years, were treated with proton-beam radiation. All had undergone at least one tumor resection. Seven patients underwent repeat resection for recurrence; one had previous x-ray radiotherapy. A daily dose of 1.8 cobalt gray equivalent was used to give a total dose in the range of 50.4-59.4 cobalt gray equivalent.


Local control was achieved in 14 of 15 patients. Twelve of 15 patients survived. There were few acute side effects. Long-term complications included newly diagnosed panhypopituitarism, a cerebrovascular accident from which the patient fully recovered, and an out-of-proton-field meningioma in the single patient who received previous radiotherapy.


Fractionated proton radiotherapy is an effective treatment for children with craniopharyngioma. Longer follow-up is needed to evaluate late complications.

[Indexed for MEDLINE]

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