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Cancer J. 2006 Mar-Apr;12(2):155-9.

Fractionated proton radiation treatment for pediatric craniopharyngioma: preliminary report.

Author information

1
Department of Radiation Medicine, Loma Linda University Medical Center, Loma Linda, California 92354, USA. qluu@dominion.llumc.edu

Abstract

This retrospective preliminary review evaluated the efficacy and toxicity of fractionated proton radiotherapy in the management of pediatric craniopharyngioma.

METHODS:

Sixteen patients, aged 7-34 years, were treated with proton-beam radiation. All had undergone at least one tumor resection. Seven patients underwent repeat resection for recurrence; one had previous x-ray radiotherapy. A daily dose of 1.8 cobalt gray equivalent was used to give a total dose in the range of 50.4-59.4 cobalt gray equivalent.

RESULTS:

Local control was achieved in 14 of 15 patients. Twelve of 15 patients survived. There were few acute side effects. Long-term complications included newly diagnosed panhypopituitarism, a cerebrovascular accident from which the patient fully recovered, and an out-of-proton-field meningioma in the single patient who received previous radiotherapy.

DISCUSSION:

Fractionated proton radiotherapy is an effective treatment for children with craniopharyngioma. Longer follow-up is needed to evaluate late complications.

PMID:
16630407
[Indexed for MEDLINE]

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