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Acta Neurol Scand. 2006 May;113(5):301-6.

Predictors of good prognosis in total anterior circulation infarction within 6 h after onset under conventional therapy.

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1
Department of Neurology, Toda Central General Hospital, Toda City, Saitama, Japan. hideaki-tei@m5.dion.ne.jp

Abstract

OBJECTIVE:

We investigated the predictors of good prognosis in total anterior circulation infarction (TACI), under conventional therapy.

METHODS:

We enrolled 166 patients with first-ever ischemic stroke within 6 h after onset with symptoms of TACI. Sixty-three patients (38.0%) with good outcome [G group, the modified Rankin Disability Scale (mRS) after 3 months < or =3] and 103 patients (62.0%) with bad outcome (B group, mRS >3) were compared.

RESULTS:

On univariate analysis, G group patients were significantly younger, had lower score in the National Institutes of Health Stroke Scale (NIHSS) of total and consciousness sub-score, had lower rate of clinical deterioration. On cranial CT at entry, three early CT signs [hyperdense middle cerebral artery (MCA) sign, hypodensity of >1/3 MCA and brain swelling] were significantly more frequent in the B group. On the second CT at 24-48 h, infarct area as assessed by the Alberta Stroke Programme Early CT Score (ASPECTS) was significantly smaller in the G group. Multivariate analysis with logistic regression revealed age <7 0 years, NIHSS < or =15, no clinical deterioration, and only no brain swelling in early CT signs, and ASPECTS > or =7 as independent predictors of good prognosis.

CONCLUSIONS:

Some clinical variables are useful in predicting outcome in TACI within the early period after stroke onset.

[Indexed for MEDLINE]

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