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Nat Rev Drug Discov. 2006 May;5(5):377-9.

Integrative pharmacology and drug discovery--is the tide finally turning?

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  • 1British Pharmacological Society, London, UK. mc@bps.ac.uk

Abstract

In vivo animal experiments are essential (and a regulatory requirement) to demonstrate the potential efficacy, safety and pharmacodynamic/pharmacokinetic profile of candidate drugs. However, the number of pharmacologists (and other bioscientists) with integrative (in vivo) pharmacology skills has been in decline for a number of years, as have the opportunities for students to learn such skills. This article reviews some recent initiatives that are underway to rebuild this essential skills base in the United Kingdom and the United States. Partnerships between industry and national funders of research and education have proved to be a particularly effective approach to support this strategically important area of biological science.

PMID:
16628199
DOI:
10.1038/nrd2036
[PubMed - indexed for MEDLINE]
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