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Arterioscler Thromb Vasc Biol. 2006 May;26(5):968-76.

Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss.

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  • 1Quebec Heart and Lung Institute, Sainte-Foy, Canada.


Obesity is becoming a global epidemic in both children and adults, and it is associated with numerous co-morbidities such as cardiovascular diseases (CVD), type 2 diabetes, hypertension, certain cancers, and sleep apnea/sleep-disordered breathing. In fact, is an independent risk factor for CVD and CVD risks have been also documented in obese children, and is associated with reduced life expectancy. A variety of adaptations/alterations in cardiac structure and function occur in the individual as adipose tissue accumulates in excess amount. As a whole, overweight/obesity predispose or is associated with numerous cardiac complications such as coronary heart disease, heart failure, and sudden death through its impact on the cardiovascular system.

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