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Brain Res. 2006 May 26;1091(1):122-31. Epub 2006 Apr 13.

Studying inner ear protein-protein interactions using FRET and FLIM.

Author information

1
Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE 68178, USA. hallw@creighton.edu

Abstract

Molecular genetic studies of the inner ear have recently revealed a large number of previously undescribed proteins, but their functions remain unclear. Optical methods such as FRET and FLIM are just beginning to be applied to the study of functional interactions between novel inner ear proteins. This review discusses the various methods for employing FRET and FLIM in protein-protein interaction studies, their advantages and pitfalls, with examples drawn from inner ear studies.

PMID:
16626648
PMCID:
PMC1992439
DOI:
10.1016/j.brainres.2006.02.076
[Indexed for MEDLINE]
Free PMC Article
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