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Clin Sci (Lond). 1991 Dec;81(6):739-42.

Anti-oxidants show an anti-hypertensive effect in diabetic and hypertensive subjects.

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Cattedra di Diabetologia e Dietoterapia I Facoltà di Medicina, Università di Napoli, Italia.


1. In this study an acute anti-hypertensive effect of three anti-oxidant agents (vitamin C, thiopronine and glutathione) in hypertensive subjects and in both hypertensive and non-hypertensive diabetic patients is reported. 2. The anti-oxidants had no effect on blood pressure in healthy normal subjects at a dose of 6 mmol, but thiopronine and glutathione produced a significant hypotensive effect at a dose of 12 mmol. 3. These data suggest that anti-oxidants might have a dilatatory effect and that an imbalance of the nitric oxide-free radical interaction might facilitate the development of hypertension in humans.

[Indexed for MEDLINE]

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