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Genetics. 2006 Jul;173(3):1813-6. Epub 2006 Apr 19.

Mapping novel traits by array-assisted bulk segregant analysis in Saccharomyces cerevisiae.

Author information

1
Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.

Abstract

We demonstrate a new method, microarray-assisted bulk segregant analysis, for mapping traits in yeast by genotyping pooled segregants. We apply a probabilistic model to the progeny of a single cross and as little as two microarray hybridizations to reliably map an auxotrophic marker, a Mendelian trait, and a major-effect quantitative trait locus.

PMID:
16624899
PMCID:
PMC1526703
DOI:
10.1534/genetics.106.057927
[Indexed for MEDLINE]
Free PMC Article

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