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Exp Parasitol. 2006 Oct;114(2):129-32. Epub 2006 Apr 19.

Plasmodium vinckei: selection of a strain exhibiting stable resistance to arteether.

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1
Division of Parasitology, Central Drug Research Institute, Lucknow 226001, India.

Abstract

A strain of rodent malaria parasite Plasmodium vinckei showing >12-fold resistance to arteether has been selected after exposure to sub-curative doses of drug in 44 sequential passages over a period of 700 days. Experimentally induced resistance was found to be stable after drug free maintenance of parasites for 11 serial passages over a period of 100 days. Cross-sensitivity studies have shown that apart form resistance to related derivatives like artemether and artesunic acid, the derived parasites also show resistance to quinine and mefloquine.

PMID:
16624307
DOI:
10.1016/j.exppara.2006.02.017
[Indexed for MEDLINE]
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