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BMC Bioinformatics. 2006 Apr 19;7:210.

An integrated system for genetic analysis.

Author information

1
Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK. simon.fiddy@well.ox.ac.uk

Abstract

BACKGROUND:

Large-scale genetic mapping projects require data management systems that can handle complex phenotypes and detect and correct high-throughput genotyping errors, yet are easy to use.

DESCRIPTION:

We have developed an Integrated Genotyping System (IGS) to meet this need. IGS securely stores, edits and analyses genotype and phenotype data. It stores information about DNA samples, plates, primers, markers and genotypes generated by a genotyping laboratory. Data are structured so that statistical genetic analysis of both case-control and pedigree data is straightforward.

CONCLUSION:

IGS can model complex phenotypes and contain genotypes from whole genome association studies. The database makes it possible to integrate genetic analysis with data curation. The IGS web site http://bioinformatics.well.ox.ac.uk/project-igs.shtml contains further information.

PMID:
16623936
PMCID:
PMC1459210
DOI:
10.1186/1471-2105-7-210
[Indexed for MEDLINE]
Free PMC Article

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