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Immunol Rev. 2006 Apr;210:86-104.

Microarray-based understanding of normal and malignant plasma cells.

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1
IRB, CHU Montpellier, Montpellier, France.

Abstract

Plasma cells (PCs) develop from B lymphocytes following stimulation by antigen and express a genetic program aimed at the synthesis of immunoglobulins. This program includes the induction of genes coding for transcription factors such as PRDM1, X-box-binding protein 1 and BHLHB3, cell-surface molecules such as CD138/syndecan-1, and for the unfolded protein response. We review how the microarray technology has recently contributed to the understanding of the biology of this rare but essential cell population and its transformation into premalignant and malignant PCs.

PMID:
16623766
PMCID:
PMC1955683
DOI:
10.1111/j.0105-2896.2006.00362.x
[Indexed for MEDLINE]
Free PMC Article
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