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Org Lett. 2006 Apr 27;8(9):1803-6.

Resin-bound dynamic combinatorial chemistry.

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1
Department of Chemistry, and The Center for Future Health, University of Rochester, Rochester, New York 14642, USA.

Abstract

[reaction: see text] Dynamic combinatorial chemistry (DCC) is a promising technique for receptor-aided selection of high-affinity ligands from equilibrating combinatorial libraries. Identification of the specific ligand(s) selected is often challenging, however, due to difficulties associated with chromatographic separation and/or mass degeneracy within the library. Herein, we describe proof-of-concept experiments demonstrating a new technique termed resin-bound DCC (RB-DCC), which provides a solution to this problem.

PMID:
16623555
DOI:
10.1021/ol060330+
[Indexed for MEDLINE]
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