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Nat Rev Immunol. 2006 May;6(5):343-57.

Potent antibody therapeutics by design.

Author information

1
Department of Antibody Technologies, Seattle Genetics Incorporated, 21823 30th Drive South East, Bothell, Washington 98021, USA. pcarter@seagen.com

Abstract

Antibodies constitute the most rapidly growing class of human therapeutics and the second largest class of drugs after vaccines. The generation of potent antibody therapeutics, which I review here, is an iterative design process that involves the generation and optimization of antibodies to improve their clinical potential.

PMID:
16622479
DOI:
10.1038/nri1837
[Indexed for MEDLINE]

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