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Nat Rev Immunol. 2006 May;6(5):417-23.

Functional signatures in antiviral T-cell immunity for monitoring virus-associated diseases.

Author information

1
Laboratory of AIDS Immunopathogenesis, Division of Immunology and Allergy, Department of Medicine, Centre Hospitalier Universitaire Vaudois, University of Lausanne, 1011 Lausanne, Switzerland. giuseppe.pantaleo@chuv.ch

Abstract

At present, we only have indirect knowledge of the protective role of antigen-specific T cells in human viral infections, and it has been difficult to show a direct correlation between quantitative and qualitative measures of T-cell immunity and virus-associated diseases. However, as described in this Opinion article, recent advances in the characterization of T-cell functions and in the development of standardized T-cell assays have led to the identification of distinct functional signatures of T-cell responses that correlate with levels of viral replication and disease activity.

PMID:
16622477
DOI:
10.1038/nri1840
[Indexed for MEDLINE]

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