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Nat Struct Mol Biol. 2006 May;13(5):462-4. Epub 2006 Apr 23.

EJC-independent degradation of nonsense immunoglobulin-mu mRNA depends on 3' UTR length.

Author information

1
Institute of Cell Biology, University of Bern, Baltzerstrasse 4, CH-3012 Bern, Switzerland.

Abstract

Inconsistent with prevailing models for nonsense-mediated mRNA decay (NMD) in mammals, the mRNA levels of immunoglobulin-mu (Ig-mu) genes with premature termination codons (PTCs) in the penultimate exon are still reduced by NMD when the intron furthest downstream is deleted. As in yeast, this exon junction complex-independent NMD of Ig-mu mRNAs depends on the distance between the termination codon and the poly(A) tail and suggests an evolutionarily conserved mode of PTC recognition.

PMID:
16622410
DOI:
10.1038/nsmb1081
[Indexed for MEDLINE]

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