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Infect Immun. 2006 May;74(5):3068-70.

Administration of antibody to the lung protects mice against pneumonic plague.

Author information

1
Defence Science and Technology Laboratory, Porton Down, Wiltshire SP4 OJQ, United Kingdom. jhill@dstl.gov.uk

Abstract

Intratracheal delivery of aerosolized monoclonal antibodies with specificity for Yersinia pestis LcrV and F1 antigens protected mice in a model of pneumonic plague. These data support the utility of inhaled antibodies as a fast-acting postexposure treatment for plague.

PMID:
16622253
PMCID:
PMC1459704
DOI:
10.1128/IAI.74.5.3068-3070.2006
[Indexed for MEDLINE]
Free PMC Article
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