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Infect Immun. 2006 May;74(5):3065-7.

The iron efflux protein ferroportin regulates the intracellular growth of Salmonella enterica.

Author information

1
Pediatric Gastroenterology Unit, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.

Abstract

We investigated the influence of the macrophage iron exporter ferroportin and its ligand hepcidin on intracellular Salmonella growth. Elevated ferroportin expression inhibited bacterial multiplication; hepcidin-induced ferroportin down-regulation enhanced it. Expression analysis of iron-responsive Salmonella genes indicated ferroportin-mediated iron deprivation. These results demonstrate a role for ferroportin in antimicrobial resistance.

PMID:
16622252
PMCID:
PMC1459754
DOI:
10.1128/IAI.74.5.3065-3067.2006
[Indexed for MEDLINE]
Free PMC Article

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