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Bioorg Med Chem Lett. 2006 Jul 1;16(13):3541-4. Epub 2006 Apr 18.

Synthesis and biological investigation of S-aryl-S-DABO derivatives as HIV-1 inhibitors.

Author information

1
Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Via De Gasperi, 2 I-53100 Siena, Italy.

Abstract

S-Aryl-S-DABO derivatives, a novel subclass of S-DABO anti-HIV-1 agents, were synthesized via Ullmann type reaction starting from the corresponding 2-thiouracils by the aid of microwave irradiation. The results of their evaluation as inhibitors of RT are reported together with their antiviral activity in cellular assays.

PMID:
16621553
DOI:
10.1016/j.bmcl.2006.03.080
[Indexed for MEDLINE]

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