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Bioorg Med Chem Lett. 2006 Jun 15;16(12):3193-6. Epub 2006 Apr 18.

Fluorophor-labeled spermidine derivatives as fluorescent markers in optical tumor imaging.

Author information

1
Department of Radiopharmaceutical Chemistry, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany. Markus.Wolf@dkfz.de

Abstract

Up-regulation of polyamine transporters on the surface of tumor cells and the internalization of biogenic polyamines by active transport processes may be exploited for the accumulation of spermidine derivatives as reporter molecules. We have synthesized and tested fluorophor-labeled spermidine derivatives for the development of a new class of intraoperative tumor imaging agents. In vitro uptake experiments and initial in vivo imaging studies illustrated that fluorophor tagged spermidine derivatives show tumor accumulation.

PMID:
16621552
DOI:
10.1016/j.bmcl.2006.03.046
[Indexed for MEDLINE]

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