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Bioorg Med Chem Lett. 2006 Jul 1;16(13):3564-8. Epub 2006 Apr 18.

2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors.

Author information

1
Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA. lin_yan@merck.com

Abstract

A series of 2-aryl(pyrrolidin-4-yl)acetic acids were synthesized and their biological activities were evaluated as agonists of S1P receptors. These analogs were able to induce lowering of lymphocyte counts in the peripheral blood of mice and were found to have good overall pharmacokinetic properties in rat.

PMID:
16621543
DOI:
10.1016/j.bmcl.2006.03.090
[Indexed for MEDLINE]

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