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Brain Res Dev Brain Res. 1991 Sep 19;62(1):17-22.

Differential effects of specific opioid receptor agonists on rat pup isolation calls.

Author information

1
Department of Developmental Psychobiology, New York State Psychiatric Institute, NY 10032.

Abstract

The possibility was investigated that specific opioid receptor types might selectively alter the production of isolation-induced ultrasonic vocalizations. Intracisternal injections of mu, delta and kappa opioid receptor agonists were administered to isolated 10-day-old rat pups. The mu receptor agonist [D-Ala2-NMe-Phe4-Gly-ol]-enkephalin (DAMGO) and delta receptor agonist [D-Pen2, D-Pen5]-enkephalin (DPDPE) both reduced the rate of isolation-induced ultrasonic calling in the absence of sedation. The kappa receptor agonist U50,488 had the opposite effect, significantly raising the rate of vocalization. Fourteen-day-old pups, with a larger delta receptor population, showed a greater sensitivity to DPDPE than was seen in the younger animals.

PMID:
1662121
[Indexed for MEDLINE]

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