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J Biol. 2006;5(2):4. Epub 2006 Apr 12.

Malaria pigment paralyzes dendritic cells.

Author information

1
Centre for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Old Road, Oxford, OX3 7LJ, UK. britta.urban@ndm.ox.ac.uk

Abstract

The capacity of malarial infection to suppress the patient's immune responses both to the parasite and to other antigens has long puzzled researchers. A prime suspect, the parasite-produced pigment hemozoin, has now been clearly shown to mediate immunosuppression by inhibiting dendritic cell activity.

PMID:
16620370
PMCID:
PMC1561485
DOI:
10.1186/jbiol37
[Indexed for MEDLINE]
Free PMC Article
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