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J Am Chem Soc. 2006 Apr 26;128(16):5312-3.

Tandem Nazarov cyclization-michael addition sequence catalyzed by an Ir(III) complex.

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1
Department of Chemistry, University of Rochester, Rochester, New York 14627, USA.

Abstract

The first examples of a tandem Nazarov cyclization/Michael addition process are described. The sequence is efficiently catalyzed by Ir[Me(CO)(dppe)(DIB)]2+ and occurs with high diastereoselectivity, creating three contiguous stereocenters. The mechanistic factors controlling the reactivity and diastereoselectivity are discussed.

PMID:
16620081
DOI:
10.1021/ja058772o
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