Format

Send to

Choose Destination

RETRACTED ARTICLE

See: Retraction Notice

Immunity. 2006 Apr;24(4):475-87.

Induction of a homeostatic circuit in lung tissue by microbial compounds.

Author information

1
Department of Medicine, University of California, San Diego, La Jolla, 92093, USA.

Abstract

TGFbeta presented and activated by integrin alphavbeta6 expressed on alveolar epithelial cells (AEC) continuously inhibits the functionality of alveolar macrophages (AM). Despite this inhibition, AM retain their ability to respond to inhaled microorganisms. Herein we describe a homeostatic circuit through which the effects of microbial products on macrophages transiently circumvent this inhibition by repressing alphavbeta6 expression on AEC. Subsequent production of matrix metalloproteinases by activated AM activates latent TGFbeta, reinduces alphavbeta6 expression, and thereby reinstates tonic inhibition of AM function. Our results reveal how AM can be activated while minimizing their potential to inflict collateral damage to the adjacent lung tissue and indicate that tissue-specific microenvironmental factors shape organ-specific defense strategies against microbial invasion.

PMID:
16618605
DOI:
10.1016/j.immuni.2006.02.008
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center