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Immunity. 2006 Apr;24(4):359-61.

Multiple paths to multispecificity.

Author information

1
Center for Advanced Research in Biotechnology, W.M. Keck Laboratory for Structural Biology, University of Maryland Biotechnology Institute, Rockville, 20850, USA.

Abstract

The limited primary antibody repertoire uses multiple mechanisms to account for the large number of potential antigens. In this issue of Immunity, Sethi et al. (2006) describe a new means for expanding the antibody repertoire, whereby a single antibody isomer binds diverse antigens at different regions of the binding site.

PMID:
16618592
DOI:
10.1016/j.immuni.2006.03.009
[Indexed for MEDLINE]
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