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Beijing Da Xue Xue Bao Yi Xue Ban. 2006 Apr 18;38(2):124-7.

[PLAC1/CP1 gene expression and autologous humoral immunity in gastric cancer patients].

[Article in Chinese]

Author information

1
Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100083, China.

Abstract

OBJECTIVE:

To investigate PLAC1/CP1 as a potential candidate gene in gastric cancer therapy.

METHODS:

Reverse transcription-polymerase chain reaction (RT-PCR) method was used to detect the expression of PLAC1/CP1 mRNA in gastric cancer tissues and paired adjacent non-cancerous tissues resected from 28 patients with gastric cancer. Specific antibodies against PLAC1/CP1 were also detected by ELISA method in gastric cancer patients.

RESULTS:

Fourteen (50%,14/28) out of the 28 gastric cancer samples were PLAC1/CP1 mRNA positive. Of the 28 serum samples tested,eight (29%,8/28) displayed positive seroreactivity against PLAC1/CP1 antigen, accounting for 57% (8/14) of PLAC1/CP1 mRNA positive samples.

CONCLUSION:

PLAC1/CP1 mRNA was expressed in high frequency and induced spontaneous antibody responses in gastric cancer patients. PLAC1/CP1 may be a valuable candidate antigen in gastric cancer immunotherapy.

PMID:
16617350
[Indexed for MEDLINE]
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