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Cardiovasc Res. 2006 Jul 15;71(2):216-25. Epub 2006 Mar 7.

Reactive oxygen species signaling in vascular smooth muscle cells.

Author information

1
Department of Medicine, Division of Cardiology, Emory University, 319 WMB, 1639 Pierce Dr. Atlanta, GA 30322, USA.

Abstract

Reactive oxygen species (ROS) have been shown to function as important signaling molecules in the cardiovascular system. Vascular smooth muscle cells (VSMCs) contain several sources of ROS, among which the NADPH oxidases are predominant. In VSMCs, ROS mediate many pathophysiological processes, such as growth, migration, apoptosis and secretion of inflammatory cytokines, as well as physiological processes, such as differentiation, by direct and indirect effects at multiple signaling levels. Therefore, it becomes critical to understand the different roles ROS play in the physiology and pathophysiology of VSMCs.

PMID:
16616906
PMCID:
PMC1934427
DOI:
10.1016/j.cardiores.2006.02.033
[Indexed for MEDLINE]
Free PMC Article

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