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Biochim Biophys Acta. 2006 Aug;1761(8):805-11. Epub 2006 Mar 24.

Membrane binding domains.

Author information

1
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892, USA. hurley@helix.nih.gov

Abstract

Eukaryotic signaling and trafficking proteins are rich in modular domains that bind cell membranes. These binding events are tightly regulated in space and time. The structural, biochemical, and biophysical mechanisms for targeting have been worked out for many families of membrane binding domains. This review takes a comparative view of seven major classes of membrane binding domains, the C1, C2, PH, FYVE, PX, ENTH, and BAR domains. These domains use a combination of specific headgroup interactions, hydrophobic membrane penetration, electrostatic surface interactions, and shape complementarity to bind to specific subcellular membranes.

PMID:
16616874
PMCID:
PMC2049088
DOI:
10.1016/j.bbalip.2006.02.020
[Indexed for MEDLINE]
Free PMC Article

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