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Community Genet. 2006;9(2):87-92.

Analysis of co-aggregation of cancer based on registry data.

Author information

1
Massachusetts General Hospital Biostatistics Center, Boston, MA 02114, USA.

Abstract

OBJECTIVE:

An exploratory analysis of co-aggregation of cancers using registry-based data.

METHODS:

We utilized sibships from over 18,000 families who had been recruited to the NCI-sponsored multi-institutional Cancer Genetics Network. The analysis assesses co-aggregation at the individual and family level and adjusts for ascertainment.

RESULTS:

We found statistically significant familial co-aggregation of lung cancer with pancreatic (adjusted p < 0.001), prostate (adjusted p < 0.003), and colorectal cancers (adjusted p = 0.004). In addition, we found significant familial co-aggregation of pancreatic and colorectal cancers (adjusted p = 0.018), and co-aggregation of hematopoietic and (non-ovarian) gynecologic cancers (adjusted p = 0.01).

CONCLUSION:

This analysis identified familial aggregation of cancers for which a genetic component has yet to be established.

PMID:
16612058
DOI:
10.1159/000091485
[Indexed for MEDLINE]
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