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Development. 2006 May;133(10):2023-32. Epub 2006 Apr 12.

Stabilization of beta-catenin impacts pancreas growth.

Author information

1
Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA.

Abstract

A recent study has shown that deletion of beta-catenin within the pancreatic epithelium results in a loss of pancreas mass. Here, we show that ectopic stabilization of beta-catenin within mouse pancreatic epithelium can have divergent effects on both organ formation and growth. Robust stabilization of beta-catenin during early organogenesis drives changes in hedgehog and Fgf10 signaling and induces a loss of Pdx1 expression in early pancreatic progenitor cells. Together, these perturbations in early pancreatic specification culminate in a severe reduction of pancreas mass and postnatal lethality. By contrast, inducing the stabilized form of beta-catenin at a later time point in pancreas development causes enhanced proliferation that results in a dramatic increase in pancreas organ size. Taken together, these data suggest a previously unappreciated temporal/spatial role for beta-catenin signaling in the regulation of pancreas organ growth.

PMID:
16611688
DOI:
10.1242/dev.02366
[Indexed for MEDLINE]
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