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Pharmacogenomics. 2006 Apr;7(3):467-73.

Chronic fatigue syndrome and high allostatic load.

Author information

1
Centers for Disease Control and Prevention, 1600 Clifton Road, MS A-15, Atlanta, GA 30333, USA. evm3@cdc.gov

Abstract

STUDY POPULATION:

We examined the relationship between chronic fatigue syndrome (CFS) and allostatic load in a population-based, case-control study of 43 CFS patients and 60 nonfatigued, healthy controls from Wichita, KS, USA.

METHODS:

An allostatic load index was computed for all study participants using available laboratory and clinical data, according to a standard algorithm for allostatic load. Logistic regression analysis was used to compute odds ratios (ORs) as estimates of relative risk in models that included adjustment for matching factors and education; 95% confidence intervals (CIs) were computed to estimate the precision of the ORs.

RESULTS:

CFS patients were 1.9-times more likely to have a high allostatic load index than controls (95% CI = 0.75, 4.75) after adjusting for education level, in addition to matching factors. The strength of this association increased in a linear trend across categories of low, medium and high levels of allostatic load (p = 0.06).

CONCLUSION:

CFS was associated with a high level of allostatic load. The three allostatic load components that best discriminated cases from controls were waist:hip ratio, aldosterone and urinary cortisol.

PMID:
16610956
DOI:
10.2217/14622416.7.3.467
[Indexed for MEDLINE]
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