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J Med Chem. 2006 Apr 20;49(8):2363-6.

Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.

Author information

1
Molecular Modeling Section, Dipartimento di Scienze Farmaceutiche, Università di Padova, via Marzolo 5, Padua, Italy.

Abstract

Casein kinase 2 (CK2) is a ubiquitous, essential, and highly pleiotropic protein kinase whose abnormally high constitutive activity is suspected to underlie its pathogenic potential in neoplasia and other diseases. Using a virtual screening approach, we have identified the ellagic acid, a naturally occurring tannic acid derivative, as a novel potent CK2 inhibitor. At present, ellagic acid represents the most potent known CK2 inhibitor (K(i) = 20 nM).

PMID:
16610779
DOI:
10.1021/jm060112m
[Indexed for MEDLINE]

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