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Nano Lett. 2006 Apr;6(4):694-8.

How to stabilize phospholipid liposomes (using nanoparticles).

Author information

1
Department of Chemical & Biomolecular Engineering, University of Illinois, Urbana, Illinois 61801, USA.

Abstract

The simple strategy of mixing phospholipid liposomes with charged nanoparticles and using sonication to mix them at low volume fraction produces particle-stabilized liposomes that repel one another and do not fuse. Subsequently, the volume fraction can be raised as high as approximately 50%, reversibly, still without fusion. In studies of liposome longevity, we verified the stability of particle-stabilized liposome suspensions with volume fraction up to 16% for up to 50 days, the longest period investigated. Fluorescent dyes were encapsulated within the particle-stabilized liposomes, without leakage. Although these particle-stabilized liposomes were stable against fusion, approximately 75% of the outer liposome surface remained unoccupied. This opens the door to using particle-stabilized liposomes in various applications.

PMID:
16608266
DOI:
10.1021/nl052455y
[Indexed for MEDLINE]

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