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Nat Rev Mol Cell Biol. 2006 Apr;7(4):276-85.

Sperm guidance in mammals - an unpaved road to the egg.

Author information

1
Department of Biological Chemistry, the Weizmann Institute of Science, 76100 Rehovot, Israel. m.eisenbach@weizmann.ac.il

Abstract

Contrary to the prevalent view, there seems to be no competition in the mammalian female genital tract among large numbers of sperm cells that are racing towards the egg. Instead, small numbers of the ejaculated sperm cells enter the Fallopian tube, and these few must be guided to make the remaining long, obstructed way to the egg. Here, we review the mechanisms by which mammalian sperm cells are guided to the egg.

PMID:
16607290
DOI:
10.1038/nrm1893
[Indexed for MEDLINE]

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