Format

Send to

Choose Destination
Pediatr Pathol. 1991 Sep-Oct;11(5):685-710.

The X-linked lymphoproliferative disease: from autopsy toward cloning the gene 1975-1990.

Author information

1
Department of Pathology, University of Nebraska Medical Center, Omaha 68198-3135.

Abstract

Although X-linked lymphoproliferative disease (XLP) is rare (1-2 males per 1 x 10(6)), it serves as a model for discerning diverse diseases caused by Epstein-Barr virus (EBV) ranging from agammaglobulinemia to fatal infectious mononucleosis following infection with the virus. The study of patients with XLP has also paved the way to understanding how EBV induce diseases in children with primary immunodeficiency diseases, organ transplant recipients, and those with acquired immunodeficiency syndrome. This review is dedicated to the memory of Gordon Vawter, M.D., who generously provided insights into the causes of pathogenesis of immune deficiency and lymphoproliferative disorders.

PMID:
1660601
DOI:
10.3109/15513819109065466
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center