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Neurosci Lett. 1991 Aug 19;129(2):315-7.

Sleep deprivation decreases mu and delta opioid receptor binding in the rat limbic system.

Author information

1
B.B. Brodie Department of Neuroscience, University of Cagliari, Italy.

Abstract

Sleep deprivation induced by the platform technique is considered to be a heavy stressful situation in rats. At the end of the sleep deprivation period (72 h) the rat displayed particular behavior characterized by wakefulness, a high degree of motor and exploratory activity, increased alertness and reactivity to environmental stimuli. Our previous results indicated that this behavior was antagonized by the administration of the opioid receptor antagonist naloxone and increased by opioid agonists. In this paper we show that concomitantly with this behavior, a decreased Bmax of mu and delta opioid receptors is present in the limbic system of these animals. These data suggest an active role of limbic mu and delta receptors in the generation of arousal and insomnia related to sleep deprivation induced stress.

PMID:
1660582
DOI:
10.1016/0304-3940(91)90489-g
[Indexed for MEDLINE]

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