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Front Neuroendocrinol. 2006 Jul;27(2):180-92. Epub 2006 Apr 17.

Hippocampal neuroplasticity induced by early-life stress: functional and molecular aspects.

Author information

1
Department of Anatomy/Neurobiology, University of California at Irvine, 92697-4475, USA.

Abstract

Whereas genetic factors contribute crucially to brain function, early-life events, including stress, exert long-lasting influence on neuronal function. Here, we focus on the hippocampus as the target of these early-life events because of its crucial role in learning and memory. Using a novel immature-rodent model, we describe the deleterious consequences of chronic early-life 'psychological' stress on hippocampus-dependent cognitive tasks. We review the cellular mechanisms involved and discuss the roles of stress-mediating molecules, including corticotropin releasing hormone, in the process by which stress impacts the structure and function of hippocampal neurons.

PMID:
16603235
PMCID:
PMC2937188
DOI:
10.1016/j.yfrne.2006.02.001
[Indexed for MEDLINE]
Free PMC Article
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