Format

Send to

Choose Destination
Respir Res. 2006 Apr 7;7:63.

Exhaled breath condensate cysteinyl leukotrienes and airway remodeling in childhood asthma: a pilot study.

Author information

1
Department of Paediatric Respiratory Medicine, Imperial College of Science, Technology and Medicine, Royal Brompton Hospital, National Heart and Lung Institute, London, UK. lex@med.uni-duesseldorf.de

Abstract

BACKGROUND:

It has been suggested that cysteinyl leukotrienes (cysLTs) play an important role in airway remodeling. Previous reports have indicated that cysLTs augment human airway smooth muscle cell proliferation. Recently, cysLTs have been measured in exhaled breath condensate (EBC). The aim of this study was to evaluate the relationship between cysLTs in EBC and another marker of airway remodeling, reticular basement membrane (RBM) thickening, in endobronchial biopsies in children.

METHODS:

29 children, aged 4-15 years, with moderate to severe persistent asthma, who underwent bronchoscopy as part of their clinical assessment, were included. Subjects underwent spirometry and EBC collection for cysLTs analysis, followed by bronchoscopy and endobronchial biopsy within 24 hours.

RESULTS:

EBC cysLTs were significantly lower in asthmatic children who were treated with montelukast than in those who were not (median (interquartile range) 36.62 (22.60-101.05) versus 249.1 (74.21-526.36) pg/ml, p = 0.004). There was a significant relationship between EBC cysLTs and RBM thickness in the subgroup of children who were not treated with montelukast (n = 13, r = 0.75, p = 0.003).

CONCLUSION:

EBC cysLTs appear to be associated with RBM thickening in asthma.

PMID:
16603074
PMCID:
PMC1456970
DOI:
10.1186/1465-9921-7-63
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center