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Virology. 1991 Dec;185(2):908-10.

Apical expression of herpes simplex virus type 2 glycoproteins in human neuroblastoma cells.

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University of Alabama, Department of Pediatrics, Birmingham 35294.


The expression of herpes simplex virus type 2 (HSV-2) glycoproteins on the surface of human neuroblastoma cells has been investigated using Millipore Millicell culture plate inserts. Utilizing a modified radioimmunoassay, we learned that glycoproteins B, C, D, E, and I were expressed predominantly on the apical membrane domain of the infected neuroblastoma cells. The unidirectional transport of HSV-2 glycoproteins was substantiated by the analysis of extracellular glycoproteins released from neuroblastoma cells. The results suggest that the evaluated HSV-2 glycoproteins were transported primarily to the apical plasma membrane domain of human neuroblastoma cells.

[Indexed for MEDLINE]

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