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Neuropsychobiology. 2006;53(3):127-32. Epub 2006 Apr 4.

Increased plasma nitric oxide metabolites in suicide attempters.

Author information

1
Department of Psychiatry, College of Medicine, Korea University, Seoul, Korea.

Abstract

OBJECTIVE:

To evaluate any correlation between plasma levels of nitric oxide metabolites (NO(x)) and suicide attempt.

METHOD:

Plasma NO(x) levels were measured in 53 patients who had recently attempted suicide, 58 non-suicidal psychiatric patients, and 75 normal controls. The severity of suicidal behaviors was evaluated using Weisman and Worden's Risk-Rescue Rating Scale.

RESULTS:

Plasma NO(x) levels were significantly higher in suicidal patients than non-suicidal psychiatric patients or normal control subjects (F=11.029, d.f.=2, 183, p<0.001). Among the patients with a diagnosis of major depression, suicidal depressive patients had significantly higher plasma NO(x) levels than non-suicidal depressive patients (t=-3.090, d.f.=84, p=0.003).

CONCLUSION:

Our study suggests that increased NO production in plasma is associated with suicide attempt, especially in depressive patients.

PMID:
16601363
DOI:
10.1159/000092542
[Indexed for MEDLINE]

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