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Fertil Steril. 2006 May;85(5):1398-403. Epub 2006 Apr 5.

Urinary follicle-stimulating hormone (FSH) is more effective than recombinant FSH in older women in a controlled randomized study.

Author information

1
Department of Obstetrics, Gynecology and Perinatology, Policlinico Umberto I Hospital, La Sapienza University, Rome, Italy.

Abstract

OBJECTIVE:

The following study was conducted to determine which FSH, recombinant or urinary, works better in older women.

DESIGN:

We conducted a controlled randomized study in a single university IVF center.

SETTING:

University IVF center.

PATIENT(S):

Women (N = 257) over 39 years old undergoing IVF.

INTERVENTION(S):

The patients were randomized into two study groups at their first IVF cycle: 121 patients were treated with recombinant FSH, and 120 patients were treated with urinary FSH. Both groups were suppressed with a long GnRH analog protocol.

MAIN OUTCOME MEASURE(S):

Days of stimulation, E2 at the day of hCG, total amount of FSH administered, number of oocytes collected, amount of FSH per oocyte, and number of embryos obtained.

RESULT(S):

Patients treated with urinary FSH required a significantly lower total amount of FSH, and a lower amount of FSH per oocyte than women treated with recombinant FSH. The other measures evaluated did not show any statistically significant differences.

CONCLUSION(S):

Our study showed that urinary FSH performed better in older women than recombinant FSH when associated with the long protocol.

[Indexed for MEDLINE]

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