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Fertil Steril. 2006 May;85(5):1364-7; discussion 1368-70. Epub 2006 Apr 5.

The play of chance.

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Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada.


Most randomized controlled trials are small relative to the clinical question they address, and chance causes more variability in the results of small trials. Thus, when small studies herald new treatment interventions, clinicians might wish to wait until the body of evidence is weighty and consistent enough to be convincing.

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