Format

Send to

Choose Destination
Cell. 1991 Nov 29;67(5):909-16.

Agrin mediates cell contact-induced acetylcholine receptor clustering.

Author information

1
Department of Molecular and Cellular Physiology, Stanford University, California 94305.

Abstract

One of the important events in synapse formation is the accumulation of neurotransmitter receptors beneath the presynaptic nerve terminal. Agrin is a component of the synaptic basal lamina that induces the clustering of acetylcholine receptors when bath-applied to muscle fibers in culture. When a cDNA encoding a putative agrin protein is transfected into cells, the molecule is secreted and concentrated on the extracellular surface. Coculture of transfected cells with muscle fibers induces the formation of receptor patches at contact sites. These results demonstrate that expression of a single gene encoding agrin confers receptor clustering that is restricted to specific sites of cell-muscle contact.

PMID:
1659950
DOI:
10.1016/0092-8674(91)90364-5
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center