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Immunol Today. 1991 Oct;12(10):356-61.

Mls--a retrovirus exploits the immune system.

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  • 1Ludwig Institute for Cancer Research, Lausanne Branch, Epalinges, Switzerland.

Abstract

The identity of minor lymphocytes stimulating (Mls) antigens, endogenous superantigens that can activate, or induce the deletion of, large portions of the T-cell repertoire, has recently been revealed: they are encoded by mouse mammary tumor viruses (MMTV) that have integrated into the germ line as DNA proviruses. As Hans Acha-Orbea and Ed Palmer point out, Mls-mediated modulation may be only the tip of the retrovirus iceberg; already murine leukemia virus (MuLV), with similar superantigen properties, has been discovered.

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PMID:
1659830
DOI:
10.1016/0167-5699(91)90066-3
[PubMed - indexed for MEDLINE]
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