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Br J Cancer. 2006 Apr 10;94(7):1041-4.

Cyclin L1 (CCNL1) gene alterations in human head and neck squamous cell carcinoma.

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1
Laboratoire de Biologie Tumorale, Centre de lutte contre le cancer Paul Strauss, 3 rue de la Porte de l'Hôpital, 67065 Strasbourg Cedex, France. btumorale@strasbourg.fnclcc.fr

Abstract

We evaluated the expression and amplification of cyclin L1 (CCNL1) gene, a potential oncogene localised in the commonly amplified 3q25-28 region, in human head and neck squamous cell carcinomas (HNSCCs). Overexpression was observed in 55 out of 96 cases (57%) and amplification in nine out of 35 tumours (26%) with no relationships to the clinico-pathological parameters. The Cyclin L1 antibody we developed labels nuclear speckles in tumour cells compatible with a role for CCNL1 in RNA splicing.

PMID:
16598186
PMCID:
PMC2361229
DOI:
10.1038/sj.bjc.6603036
[Indexed for MEDLINE]
Free PMC Article
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