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Biochem Biophys Res Commun. 1991 Nov 27;181(1):184-90.

Cloning and chromosomal localization of a human endothelin ETA receptor.

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  • 1Department of Pharmacology, New York University Medical Center, New York 10016.


A cDNA clone encoding a human endothelin receptor was isolated from a placenta cDNA library. The deduced amino acid sequence of the clone is 94% identical to the bovine endothelin ETA receptor and represents the human homologue. The human endothelin ETA receptor gene was localized to chromosome 4 by analysis of its segregation pattern in rodent-human hybrids.

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