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Nature. 1991 Nov 28;354(6351):278-84.

Structure of simian virus 40 at 3.8-A resolution.

Author information

1
Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts 02138.

Abstract

The crystallographically determined structure of simian virus 40 shows that the 72 pentamers of viral protein VP1, which form the outer shell, have identical conformations except for the C-terminal arms of their subunits. Five arms emerge from each pentamer and insert into neighbouring pentamers. This tying together of standard building blocks allows for the required variability in packing geometry without sacrificing specificity.

PMID:
1659663
DOI:
10.1038/354278a0
[Indexed for MEDLINE]

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