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Cell Mol Life Sci. 2006 Jun;63(12):1331-54.

Sialic acid-specific lectins: occurrence, specificity and function.

Author information

1
Institute for Glycomics, Griffith University, Gold Coast Campus, PMB 50, Gold Coast Mail Centre, 9726 Australia. f.lehmann@griffith.edu.au

Abstract

Sialic acids consist of a family of acidic nine-carbon sugars that are typically located at the terminal positions of a variety of glycoconjugates. Naturally occurring sialic acids show an immense diversity of structure, and this reflects their involvement in a variety of biologically important processes. One such process involves the direct participation of sialic acids in recognition events through specific interactions with lectins, a family of proteins that recognise and bind sugars. This review will present a detailed overview of our current knowledge regarding the occurrence, specificity and function of sialic acid-specific lectins, particularly those that occur in viruses, bacteria and non-vertebrate eukaryotes.

PMID:
16596337
DOI:
10.1007/s00018-005-5589-y
[Indexed for MEDLINE]

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