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Eur J Pharmacol. 1991 Jun 25;199(2):259-62.

Blockade of neurotransmitter-activated K+ conductance by QX-314 in the rat hippocampus.

Author information

1
Department of Pharmacological and Physiological Sciences, St. Louis University School of Medicine, MO 63104.

Abstract

Intracellular injection of QX-314 blocked the ability of baclofen and 5-carboxyamidotryptamine to hyperpolarize cells in the rat hippocampus. This effect was not associated with a reduction in the effects of norepinephrine on these cells nor a blockade of the potassium channels underlying the calcium-dependent afterhyperpolarization responsible or significant changes in membrane potential. These results suggest that QX-314 is an effective blocker of G-protein-gated potassium channels in this region.

PMID:
1659537
DOI:
10.1016/0014-2999(91)90467-5
[Indexed for MEDLINE]

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